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Table 4 Association of MTL metabolism with UPDRS motor score

From: Alteration of medial temporal lobe metabolism related to Alzheimer’s disease and dementia with lewy bodies

 

UPDRS

 

β

P

AD spectrum

  

Left amygdala

0.181

0.001

Right amygdala

0.187

0.001

Left hippocampus

0.148

0.010

Right hippocampus

0.130

0.023

Left entorhinal cortex

0.123

0.036

Right entorhinal cortex

0.158

0.006

DLB spectrum

  

Left amygdala

0.216

< 0.001

Right amygdala

0.227

< 0.001

Left hippocampus

0.162

0.004

Right hippocampus

0.146

0.009

Left entorhinal cortex

0.131

0.022

Right entorhinal cortex

0.178

0.002

Disease group

  

Left amygdala

0.191

< 0.001

Right amygdala

0.174

0.001

Left hippocampus

0.179

< 0.001

Right hippocampus

0.155

0.002

Left entorhinal cortex

0.163

0.002

Right entorhinal cortex

0.161

0.002

  1. The data are the results of univariable general linear models for the UPDRS motor score using MTL metabolism as a predictor after controlling for age, sex, and education. Significant P-values are shown in boldface after false discovery rate correction for multiple statistical tests across the six MTL regions. Analyses were performed separately on the AD spectrum (NC + AD + MD), DLB spectrum (NC + DLB + MD), and in the disease group (AD + DLB + MD). β = standardized beta coefficient. Abbreviations: AD, Alzheimer’s disease; DLB, dementia with Lewy bodies; MD, mixed disease; MTL, medial temporal lobe; NC, normal control; UPDRS, Unified Parkinson’s Disease Rating Scale
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Alzheimer's Research & Therapy

ISSN: 1758-9193