Alteration of medial temporal lobe metabolism related to Alzheimer’s disease and dementia with lewy bodies

Table 1 Comparison of demographic data among the NC, AD, DLB, MD groups

	NC (N = 28)	AD (N = 131)	DLB (N = 133)	MD (N = 122)	P value
Age, y	61.93 ± 7.40	74.15 ± 7.92^*	74.44 ± 6.47^*	73.24 ± 7.63^*	< 0.001
Education, y	14.30 ± 4.34	10.71 ± 5.10^*	9.80 ± 5.32^*	9.41 ± 5.13^*	< 0.001
Female, n (%)	16 (57.1%)	84 (64.1%)	72 (54.1%)	88 (72.1%)^‡	0.026
K-MMSE	29.04 ± 1.07	22.44 ± 4.11^*	22.90 ± 4.26^*	20.87 ± 4.91^*,†,‡	< 0.001
CDR	0.04 ± 0.13	0.59 ± 0.23^*	0.66 ± 0.33^*	0.78 ± 0.38^*,†,‡	< 0.001
Stages					0.001
MCI, n (%)	-	70 (53.4%)	77 (57.9%)	44 (36.1%)^†,‡
Dementia, n (%)	-	61 (46.6%)	56 (42.1%)	78 (63.9%)^†,‡
UPDRS	0.96 ± 2.38	17.85 ± 10.47^*	20.29 ± 9.70^*	20.65 ± 10.90^*,†	< 0.001
Cognitive fluctuation	0 (0%)	0 (0%)	107 (80.5%)^*,†	101 (82.8%)^*,†	< 0.001
Visual hallucination	0 (0%)	0 (0%)	22 (16.5%)^*,†	22 (18.0%)^*,†	< 0.001
RBD	0 (0%)	12 (9.2%)	39 (29.3%)^*,†	28 (23.0%)^*,†	0.008

Data are expressed as means (SD) or numbers (%). Group comparisons were performed using the chi-square test or analysis of variance, as appropriate
^*Significantly different from NC after false discovery method correction. ^†Significantly different from AD after false discovery method correction. ^‡Significantly different from DLB after false discovery method correction
Abbreviations: AD, Alzheimer’s disease; CDR, clinical dementia rating; DLB, dementia with Lewy bodies; K-MMSE, Korean-mini-mental state examination; MCI, mild cognitive impairment; MD, mixed disease; NC, normal cognition; RBD, rapid eye movement sleep behavior disorder; UPDRS, Unified Parkinson’s Disease Rating Scale

ISSN: 1758-9193