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Table 4 Plasma NfL’s associations with brain structures in the full sample

From: Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men

Model: Brain Structures ∼ Age + Health Status + Young Adult GCA + Plasma NfL

Outcomes (Sample Size)

Beta Estimate

95% CI

[upper, lower]

Uncorrected

P value

FDR-corrected P value

Mean Cortical Thickness (N = 451)

-0.001

[-0.01, 0.01]

0.841

0.565

Hippocampal Volume (N = 398)

-23.68

[-82.75, 35.38]

0.432

0.406

Cortical MD (N = 330)

0.000

[-0.005, 0.005]

0.904

0.565

FA of White Matter Tracts (N = 330)

-0.001

[-0.003, 0.001]

0.387

0.406

MD of White Matter Tracts (N = 330)

0.002

[-0.001, 0.005]

0.206

0.406

WMH (N = 414)

0.005

[0.001, 0.009]

0.007

0.035

AD thickness/volume signature (N = 382)

-0.125

[-0.477, 0.227]

0.487

0.406

MD signature (N = 278)

0.258

[-0.267, 0.783]

0.336

0.406

  1. Note: N = Plasma NfL’s beta estimates, 95% CI, and p values are shown. Significant associations with cognitive domains are shown in bold. WMH = White Matter Hyperintensity, MD = Mean Diffusivity, FA = Fractional Anisotropy
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Alzheimer's Research & Therapy

ISSN: 1758-9193