Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men

Table 3 Plasma NfL’s associations with cognition in CU and MCI groups

Model: Cognitive Domain ∼ Age + Health Status + Young Adult GCA + Plasma NfL
Outcomes	Beta Estimate	95% CI [upper, lower]	Uncorrected P value	FDR-corrected P value
CU
Executive Function	-0.06	[-0.12, -0.01]	0.024	0.096
Episodic Memory	-0.03	[-0.09, 0.04]	0.425	0.340
Verbal Fluency	-0.05	[-0.12, 0.01]	0.123	0.123
Processing Speed	-0.05	[-0.12, 0.01]	0.111	0.123
Visual-spatial Ability	-0.05	[-0.10, 0.01]	0.085	0.123
MCI
Executive Function	0.10	[-0.05, 0.24]	0.186	0.248
Episodic Memory	-0.15	[-0.31, 0.01]	0.066	0.132
Verbal Fluency	-0.01	[-0.16, 0.15]	0.913	0.730
Processing Speed	-0.39	[-0.58, -0.19]	< 0.0001	0.0004
Visual-spatial Ability	-0.01	[-0.14, 0.11]	0.836	0.730

Note: For CU, N = 814, except processing speed N = 813 and visual-spatial ability N = 812. For MCI, N = 142. Plasma NfL’s beta estimates, 95% CI, and p values are shown. Significant associations with cognitive domains are shown in bold

ISSN: 1758-9193