Table 2 Individual and combined effects of the association of BW cycle and BW variability (VIM quartile) with incident dementia (Data are hazard ratios with 95% CI.)
BW cycle only | VIM Q1 | VIM Q2 | VIM Q3 | VIM Q4 | ||
|---|---|---|---|---|---|---|
VIM only | – | 1.0 (ref) | 1.08 (1.04–1.12) | 1.23 (1.18–1.28) | 1.52 (1.47–1.58) | |
< 3% (N = 1,166,108) | 1.0 (ref) | 1.0 (ref) | 1.10 (1.03–1.18) | 1.15 (1.07–1.23) | 1.46 (1.37–1.56) | |
3% | 1 time (N = 1,250,801) | 1.07 (1.04–1.11) | 1.03 (0.96–1.10) | 1.03 (0.96–1.11) | 1.23 (1.13–1.33) | 1.40 (1.28–1.53) |
≥ 2 times (N = 1,219,079) | 1.13 (1.09–1.17) | 0.93 (0.84–1.03) | 1.13 (1.04–1.23) | 1.28 (1.16–1.40) | 1.35 (1.22–1.50) | |
5% | 1 time (N = 969,925) | 1.16 (1.12–1.20) | 0.91 (0.78–1.07) | 1.09 (1.02–1.17) | 1.28 (1.19–1.37) | 1.51 (1.39–1.63) |
≥ 2 times (N = 414,193) | 1.25 (1.19–1.30) | 1.20 (0.68–2.12) | 0.98 (0.85–1.13) | 1.26 (1.12–1.40) | 1.57 (1.38–1.77) | |
7% | 1 time (N = 516,383) | 1.22 (1.18–1.27) | None | 0.97 (0.82–1.14) | 1.27 (1.18–1.36) | 1.48 (1.38–1.59) |
≥ 2 times (N = 115,333) | 1.49 (1.39–1.60) | None | 1.02 (0.38–2.71) | 1.29 (1.07–1.56) | 1.69 (1.48–1.93) | |
10% | 1 time (N = 183,968) | 1.35 (1.28–1.43) | None | None | 1.08 (0.85–1.37) | 1.64 (1.53–1.75) |
≥ 2 times (N = 21,385) | 2.00 (1.74–2.29) | None | None | None | 2.37 (2.05–2.74) | |