Table 1 Baseline characteristics of the study cohort
Total (N = 3,635,988) | Non–dementia (N = 3,614,928) | Dementia (N = 21,060) | ||
|---|---|---|---|---|
Age, years | 51.1 ± 6.54 | 51.10 ± 6.53 | 58.55 ± 4.65 | |
Female (%) | 1,223,013 (33.64) | 1,212,809 (33.55) | 10,204 (48.45) | |
BMI | 24.01 ± 2.91 | 24.01 ± 2.91 | 23.96 ± 2.97 | |
SBP | 122.77 ± 14.09 | 122.76 ± 14.09 | 124.62 ± 15.18 | |
DBP | 77.24 ± 9.85 | 77.24 ± 9.85 | 77.44 ± 10.01 | |
Total cholesterol | 198.87 ± 35.91 | 198.87 ± 35.90 | 198.60 ± 38.55 | |
eGFR | 88.26 ± 14.63 | 88.28 ± 14.62 | 84.85 ± 14.84 | |
Health–related behaviors | ||||
Smoking status (%) | ||||
Never smoker | 1,887,224 (51.99) | 1,873,761 (51.92) | 13,463 (64.02) | |
Ex–smoker | 806,122 (22.21) | 802,752 (22.24) | 3,370 (16.02) | |
Current Smoker | 934,858 (25.81) | 932,660 (25.84) | 4,198 (19.96) | |
Alcohol intake (%) | ||||
None | 1,674,203 (46.05) | 1,661,091 (45.95) | 13,112 (62.26) | |
< 10 g/day | 924,726 (25.43) | 921,090 (25.48) | 3,636 (17.26) | |
10–19.9 g/day | 478,530 (13.16) | 476,781 (13.19) | 1,749 (8.30) | |
20–39.9 g/day | 411,834 (11.33) | 410,172 (11.35) | 1,662 (7.89) | |
≥ 40 g/day | 146,695 (4.03) | 145,794 (4.03) | 901 (4.28) | |
Physical activity (METS) (%) | ||||
Low (< 600) | 1,197,822 (32.94) | 1,189,512 (32.91) | 8,310 (39.46) | |
Moderate (600–3000) | 1,993,797 (54.84) | 1,983,758 (54.88) | 10,039 (47.67) | |
High (≥ 3000) | 444,369 (12.22) | 441,658 (12.22) | 2,711 (12.87) | |
Medical history (%) | ||||
HTN | 2,030,032 (55.83) | 2,015,379 (55.75) | 14,653 (69.58) | |
DM | 918,510 (25.26) | 911,053 (25.20) | 7,457 (35.41) | |
Heart disease | 50,277 (1.38) | 49,553 (1.37) | 724 (3.44) | |
Stroke | 17,692 (0.49) | 17,224 (0.48) | 468 (2.22) | |
Family history (%) | ||||
HTN | 1,387,633 (38.16) | 1,380,319 (38.18) | 7,314 (34.73) | |
DM | 930,071 (25.58) | 925,056 (25.59) | 5,015 (23.81) | |
Heart disease | 476,735 (13.11) | 474,388 (13.12) | 2,347 (11.14) | |
Stroke | 733,078 (20.16) | 728,572 (20.15) | 4,506 (21.40) | |