Table 1 Baseline characteristics
|  | Presymptomatic D-CAA n = 28 | Symptomatic D-CAA n = 29 | Sporadic CAA n = 59 | Controls < 55y n = 33 | Controls ≥ 55y n = 38 |
|---|---|---|---|---|---|
Age, y, mean (range) | 40.4 (27–55) | 58.1 (43–74) | 71.7 (57–86) | 42.4 (27–54) | 64.8 (55–85) |
Women, n (%) | 18 (64.3) | 14 (48.3) | 25 (42.4) | 16 (48.5) | 14 (36.8) |
Education > 12y, n (%) | 19 (67.9) | 12 (41.4) | 37 (62.7)a | - | - |
Previous symptomatic ICH, n (%) | - | 29 (100) | 30 (50.8) | - | - |
Time between ICH and blood/CSF withdrawal in months, median (range) | - | 22 (2–85) | 14 (2–87) | - | - |
Cognitive testing performed, n (%) | 28 (100) | 29 (100) | 51 (86.4) | - | - |
MoCA, median (range) | 28 (24-30) | 27 (15-30) | 25.5 (8-30)b | - | - |
MRI data available, n (%) | 25 (89.3) | 27 (93.1) | 55 (93.2) | - | - |
Macrobleed count, median (range) | 0 (0–0) | 4 (1-26) | 0 (0–13) | - | - |
CAA CSVD score, median (range) | 1 (0–4) | 4 (3-60 | 4 (0–6) | - | - |
CSF Aβ40 (pg/mL), median (range)c | 2184 (832–3752) | 1733.5 (910–2702) | 6125 (1642–12,029) | 7551.5 (2889–14,874) | 9036 (3905–16,305) |
CSF Aβ42 (pg/mL), median (range)d | 102 (41–184) | 76 (41–106) | 312.5 (72–1088) | 629 (233–1578) | 681 (326–1265) |
CSF p-tau (pg/mL), median (range)e | - | - | 45.2 (24.5–207.1) | 22.9 (11–49) | 33.8 (18–94.7) |