Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea

Chun, Min Young; Chae, Wonjeong; Seo, Sang Won; Jang, Hyemin; Yun, Jihwan; Na, Duk L.; Kang, Dongwoo; Lee, Jungkuk; Hammers, Dustin B.; Apostolova, Liana G.; Jang, Sung-In; Kim, Hee Jin

doi:10.1186/s13195-024-01436-5

Alzheimer's Research & Therapy

Table 2 All-cause mortality and related factors among early-onset dementia and late-onset dementia individuals

From: Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea

Variables	Early-onset dementia (n = 2,368)					Late-onset dementia (n = 32,893)
Variables	Death (n)	%	Non-death (n)	%	p value	Death (n)	%	Non-death (n)	%	p value
Total Participants	442	18.7	1,926	81.3		12,969	39.4	19,924	60.6
Age					< 0.001					< 0.001
Mean ± Standard deviation	54.8 ± 5.2		52.6 ± 5.1			77.2 ± 6.8		72.1 ± 5.76
Sex					< 0.001					< 0.001
Male	310	70.1	926	48.1		5,087	39.2	5,638	28.3
Female	132	29.9	1,000	51.9		7,882	60.8	14,286	71.7
Risk factors of interest
Hypertension	224	50.7	833	43.3	0.005	9,782	75.4	14,119	70.9	< 0.001
Diabetes mellitus	205	46.4	705	36.6	< 0.001	6,832	52.7	10,311	51.8	0.100
Atrial fibrillation	16	3.6	38	2.0	0.037	752	5.8	812	4.1	< 0.001
Hyperlipidemia	179	40.5	810	42.1	0.549	5,991	46.2	10,765	54.0	< 0.001
Osteoporosis	54	12.2	363	18.8	0.001	5,806	44.8	9,883	49.6	< 0.001
Other risk factors in the Charlson comorbidity index
Myocardial infarct	59	13.3	139	7.2	< 0.001	2,293	17.7	3,026	15.2	< 0.001
Congestive heart failure	31	7.0	62	3.2	< 0.001	1,785	13.8	1,898	9.5	< 0.001
Peripheral vascular disease	105	23.8	452	23.5	0.898	5,407	41.7	8,425	42.3	0.286
Cerebrovascular disease	110	24.9	389	20.2	0.029	4,083	31.5	5,602	28.1	< 0.001
Chronic pulmonary disease	166	37.6	767	39.8	0.379	7,716	59.5	11,751	59.0	0.352
Rheumatic or connective tissue disease	10	2.3	30	1.6	0.300	346	2.7	579	2.9	0.202
Gastric or peptic ulcer	178	40.3	822	42.7	0.355	6,494	50.1	11,229	56.4	< 0.001
Mild liver disease	254	57.5	1,100	57.1	0.892	6,713	51.8	11,534	57.9	< 0.001
Hemiplegia or paraplegia	45	10.2	107	5.6	< 0.001	634	4.9	699	3.5	< 0.001
Moderate or severe renal disease	28	6.3	44	2.3	< 0.001	628	4.8	608	3.1	< 0.001
Socioeconomic status					0.348					0.848
Upper 20%	68	15.4	332	17.2		4,265	32.9	6,532	32.8
Lower 80%	374	84.6	1,594	82.8		8,704	67.1	13,392	67.2
Residential area					0.975					0.618
Urban	189	42.8	822	42.7		4,828	37.2	7,363	37.0
Rural	253	57.2	1,104	57.3		8,141	62.8	12,561	63.0

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ISSN: 1758-9193

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